It requires a powerful machine
I am running the game with Lion on a MacBook Pro 15" 2.5 i5, 8GB and Nvidia 330. It runs smoothly as long as the graphic settings are low. Do not expect to enjoy a wonderful graphic experience unless you have a really powerful mac. You wont be able to play the game on a MacMini or a MacBook Air.
Regarding the game itself, so far I am loving it. The story plot is darker and less linear, you play different phases that already took place in the past. The AI of the enemies has improved and now the seem "smarter" when looking for Sam. A good game despite of the hardware issues. It is clear that Apple computers are not built for gaming.
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Tom Clancy's Splinter Cell Conviction®